About Us

Our lab aims to develop molecular and cellular solutions to address important challenges in the biomedical sciences and clinical medicine, especially in the areas of imaging and diagnostics. We create small molecules, engineered proteins and cell-based tools that can "light up" and control in vivo biology using principles of chemical and synthetic biology. When possible, our technologies are translated to the clinic using nuclear medicine and molecular imaging techniques. For example, our group recently pioneered the development, preclinical testing, and human application of a new class of positron emission tomography (PET) radiotracers based on the small molecule antibiotic trimethoprim. These molecules have diverse applications in our broad fields of investigation including cancer biology, immunology, and infectious disease. If you have any questions about who we are and what we do, don't hesitate to reach out to us!
 

 

Announcements

  • Lab Tech Wanted – Launch Your Career in Theranostics!

    Ready to step into the rapidly growing field of theranostics? Our multidisciplinary lab is recruiting a lab technician (Bachelor’s-level graduate) to support innovative research projects spanning in vitro and in vivo studies. You’ll work alongside scientists from diverse backgrounds on cutting-edge research in radiopharmaceuticals and molecular imaging.

    What we’re looking for:

    - High integrity and strong collegial values - Passion for experimental science and data-driven discovery - Experience (or strong interest) in molecular biology, cell culture, animal studies, and/or nuclear imaging

    This is an ideal role for someone eager to grow scientifically while contributing to impactful translational research. Please click here to apply and share with interested candidates!

  • Mark got tenure!!

    A huge congratulations to our fearless leader Mark on being promoted to Associate Professor with Tenure! In addition to leading our research group, Mark has leads the Center for Translational Chemical Biology and plays an integral role as a liaison between the Department of Biochemistry & Biophysics and the MSTP, particularly with regards to admissions. Congratulations Mark on this well-deserved achievement!

  • Recent publications!

    The lab is ending the year with a slew of new publications! Congrats to all working on Anthony's Molecular Imaging & Biology paper on 11C-trimethoprim human biodistribution, Jonathan's npj Imaging perspective on clinical translation of adoptive cell therapy PET imaging, Nitika's Nature Communications manuscript on photoresponsive trimethoprim-PROTACs, and Hwan's Journal of Nuclear Medicine paper on the impact of subcellular localization on alpha particle cytotoxicity. Click here for links to these papers. Congrats again to all!